Agosterol A Explained

Agosterol A is a bio-active sterol which may have applications in removing multi-drug resistance in various cancers.[1] [2] It was first isolated from marine sponge but has also been produced synthetically.[3]

Notes and References

  1. Chen. Zhe-Sheng. Aoki. Shunji. Komatsu. Masaharu. Ueda. Kazumitsu. Sumizawa. Tomoyuki. Furukawa. Tatsuhiko. Okumura. Hiroshi. Ren. Xiao-Qin. Belinsky. Martin G.. Lee. Kun. Kruh. Gary D.. Kobayashi. Motomasa. Akiyama. Shin-ichi. Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function. International Journal of Cancer. 93. 1. 2001. 107–113. 0020-7136. 10.1002/ijc.1290. 11391629 . free.
  2. Aoki. Shunji. Chen. Zhe-Sheng. Higasiyama. Kimihiko. Setiawan. I. Akiyama. Shin-ichi. Kobayashi. Motomasa. Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells. Japanese Journal of Cancer Research. 92. 8. 2001. 886–895. 0910-5050. 10.1111/j.1349-7006.2001.tb01177.x. 11509122 . 5926837.
  3. Murakami. Nobutoshi. Sugimoto. Masanori. Morita. Mari. Kobayashi. Motomasa. Total Synthesis of Agosterol A: an MDR-Modulator from a Marine Sponge. Chemistry: A European Journal. 7. 12. 2001. 2663–2670. 0947-6539. 10.1002/1521-3765(20010618)7:12<2663::AID-CHEM26630>3.0.CO;2-U. 11465457 .

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