| Agios Panteleimonas Greek Orthodox Church | |
| Other Name: | Άγιος Παντελεήμωνας Ἑλληνορθόδοξη Ἑκκλησία Aya Panteleimon Rum Ortodoks Kilisesi |
| Pushpin Map: | Turkey Istanbul |
| Map Caption: | Location of the church in Istanbul. |
| Coordinates: | 41.0344°N 29.0303°W |
| Location: | Kuzguncuk, Istanbul |
| Country: | Turkey |
| Denomination: | Greek Orthodox |
| Dedication: | Saint Pantaleon |
Agios Panteleimonas Greek Orthodox Church (Άγιος Παντελεήμωνας Ἑλληνορθόδοξη Ἑκκλησία, Turkish: Ayios Panteleimon Rum Ortodoks Kilisesi) is a Greek Orthodox church dedicated to Saint Pantaleon located in Kuzguncuk neighborhood of Üsküdar district in Istanbul, Turkey.
The church was opened to worship during the reign of Ottoman Sultan Mahmud II in 1831. In 1872, the church building had a fire. Designed by architect Nikola Ziko, a new construction began in 1890. Two years later, the church reopened to service.
The church building is designed in Greek cross form of Byzantine architecture. The dome covering the central part of the building is carried by four pillars. The belfry, built by Andon Hüdaverdioğlu of Kuzguncuk in 1911, is situated over the marble courtyard entrance gate. Just on the street beside the church, a small square-plan holy well (ἁγίασμα, pr. hagiasma, Turkish: ayazma) is situated.