Agelasimine Explained

Agelasimines are a group of adenine-related bicyclic diterpenoids isolated from the orange sponge Agelas mauritania.[1] Their chemical structures are closely related to the agelasines.

Both groups of compounds display a range of biological activities, such as cytotoxicity, inhibition of adenosine transfer into rabbit erythrocytes (red blood cells), Ca2+ channel antagonistic action, α1 adrenergic blockade and others.[2] [3]

Both compounds have been reproduced in the laboratory by organic synthesis.

Notes and References

  1. Ohba. Masashi. Iizuka. Kazuaki. Ishibashi. Hiroyuki. Fujii. Tozo. Syntheses and absolute configurations of the marine sponge purines (+)-agelasimine-A and (+)-agelasimine-B. Tetrahedron. December 1997. 53. 50. 16977–16986. 10.1016/S0040-4020(97)10120-X.
  2. Fathi-Afshar. R.. Allen. T. M.. Biologically active metabolites from. Canadian Journal of Chemistry. January 1988. 66. 1. 45–50. 10.1139/v88-006. free.
  3. Fathi-Afshar. R.. Allen. T. M.. Krueger. C. A.. Cook. D. A.. Clanachan. A. S.. Vriend. R.. Baer. H. P.. Cass. C. E.. Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge. Canadian Journal of Physiology and Pharmacology. April 1989. 67. 4. 276–281. 10.1139/y89-045.

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