| Tourney Name: | African Cup of Champions Clubs |
| Year: | 1981 |
| Num Teams: | 31 |
| Confederations: | 1 |
| Champion Other: | JE Tizi Ouzou |
| Count: | 1 |
| Second Other: | AS Vita Club |
| Matches: | 53 |
| Goals: | 145 |
| Prevseason: | 1980 |
| Nextseason: | 1982 |
The African Cup of Champions Clubs 1981 was the 17th edition of the annual international club football competition held in the CAF region (Africa), the African Cup of Champions Clubs. It determined that years club champion of association football in Africa.
The tournament was played by 31 teams and was used a playoff scheme with home and away matches. JE Tizi Ouzou from Algeria won that final, and became for the first time CAF club champion.
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The top scorers from the 1981 African Cup of Champions Clubs are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 |  Mahmoud El Khatib | Al Ahly | 6 |
| 2 | Ali Belahcène | JE Tizi Ouzou | 5 |
| 3 | Mohamed Abbas | Al Ahly | 4 |
| 4 | Lyès Bahbouh | JE Tizi Ouzou | 3 |
| 5 | Bobo | AS Vita Club | 2 |
| Mostafa Younis | Al Ahly | 2 | |
 Lucien Kassi-Kouadio | ASEC Mimosas | 2 |
JE Tizi Ouzou (Jeunesse Eléctronique de Tizi Ouzou) are now called JS Kabylie (Jeunesse Sportive de Kabylie).