| Afrânio | |
| Settlement Type: | Municipality |
| Official Name: | The Municipality of Afrânio |
| Pushpin Map: | Brazil |
| Mapsize: | 250px |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Type2: | State |
| Subdivision Name: |  Brazil |
| Subdivision Name1: | Northeast |
| Subdivision Name2: | Pernambuco |
| Leader Title: | Mayor |
| Leader Name: | Carlos Cavalcanti (PTB) |
| Established Title: | Founded |
| Established Date: | December 20, 1963 |
| Area Total Km2: | 1490.6 |
| Population As Of: | 2020 [1] |
| Population Total: | 19,810 |
| Population Density Km2: | 11.7 |
| Timezone: | BRT |
| Utc Offset: | -3 |
| Utc Offset Dst: | 08º30'54" S, 41º00'18" O |
| Coordinates: | -8.515°N -41.005°W |
| Elevation M: | 522 |
| Blank Name: | HDI (2000) |
| Blank Info: | 0.634 – medium[2] |
Afrânio is a Brazilian municipality in the state of Pernambuco. It is the westernmost municipality of Pernambuco. It is located in the mesoregion of São Francisco Pernambucano . Afrânio has a total area of 1490.6 square kilometers and had an estimated population of 19,810 inhabitants in 2020 according with IBGE.
The main economic activities in Afrânio are based in general commerce and agribusiness, especially plantations of beans and corn; and creations of sheep, goats, donkeys and cattle.