| Official Name: | Afonino |
| Native Name: | Афонино |
| Settlement Type: | Selo |
| Pushpin Map: | Russia Altai Krai#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Name1: | Altai Krai |
| Subdivision Name3: | Zarinsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +7:00 |
| Coordinates: | 53.7667°N 99°W[1] |
Afonino (Russian: Афонино) is a rural locality (a selo) in Novodrachyoninsky Selsoviet, Zarinsky District, Altai Krai, Russia. The population was 178 as of 2013.[2] There are 5 streets.
Afonino is located 44 km northeast of Zarinsk (the district's administrative centre) by road. Zmaznevo is the nearest rural locality.[3]