Afloqualone Explained

Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.^[1] It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABA_a receptor^[2] and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.^[3]

See also

• Diproqualone
• Etaqualone
• Methylmethaqualone
• Mecloqualone
• Mebroqualone
• Cloroqualone
• Nitromethaqualone

Notes and References

1. US . 3966731 . 2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone . Inoue I, Oine T, Yamada Y, Tani J, Ishida R, Ochiai T. Tanabe Seiyaku Co Ltd . 29 June 1976 .
2. Ochiai T, Ishida R . Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity . Japanese Journal of Pharmacology . 32 . 3 . 427–38 . June 1982 . 7109348 . 10.1254/jjp.32.427 . free .
3. Ishikawa T, Kamide R, Niimura M . Photoleukomelanodermatitis (Kobori) induced by afloqualone . The Journal of Dermatology . 21 . 6 . 430–3 . June 1994 . 8064007 . 10.1111/j.1346-8138.1994.tb01768.x . 7486566 .