Afamin Explained

Afamin is a protein that in humans is encoded by the AFM gene.^{[1] [2]}

Function

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.

Further reading

• Noppe M, Lowenthal A, Karcher D, Gheuens J . A two-site immunoradiometric assay for the determination of alpha-albumin . J. Immunol. Methods . 27 . 1 . 75–81 . 1979 . 37276 . 10.1016/0022-1759(79)90240-0.
• Hansson E, Rönnbäck L, Lowenthal A, Noppe M . Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis . Brain Res. . 353 . 2 . 175–85 . 1985 . 4041902 . 10.1016/0165-3806(85)90206-8.
• Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP . Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland . J. Neurochem. . 38 . 3 . 863–5 . 1982 . 7035619 . 10.1111/j.1471-4159.1982.tb08714.x . 40660858 .
• Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L . Identification of rat alpha-albumin and cDNA cloning of its human ortholog . Gene . 153 . 2 . 287–8 . 1995 . 7875606 . 10.1016/0378-1119(94)00745-E.
• Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A . Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription . J. Mol. Biol. . 259 . 1 . 113–9 . 1996 . 8648639 . 10.1006/jmbi.1996.0306.
• Nishio H, Dugaiczyk A . Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family . Proc. Natl. Acad. Sci. U.S.A. . 93 . 15 . 7557–61 . 1996 . 8755513 . 38784 . 10.1073/pnas.93.15.7557 . 1996PNAS...93.7557N . free.
• Song YH, Naumova AK, Liebhaber SA, Cooke NE . Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster . Genome Res. . 9 . 6 . 581–7 . 1999 . 10400926 . 310762 . 10.1101/gr.9.6.581.
• Khan MA, Kumar Y, Tayyab S . Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin . Int. J. Biol. Macromol. . 30 . 3–4 . 171–8 . 2003 . 12063119 . 10.1016/S0141-8130(02)00017-X.
• Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H . Characterization of the vitamin E-binding properties of human plasma afamin . Biochemistry . 41 . 49 . 14532–8 . 2003 . 12463752 . 10.1021/bi026513v.
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR . Screening for N-glycosylated proteins by liquid chromatography mass spectrometry . Proteomics . 4 . 2 . 454–65 . 2004 . 14760718 . 10.1002/pmic.200300556 . 29261009.
• Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H . Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression . J. Proteome Res. . 4 . 3 . 889–99 . 2005 . 15952736 . 10.1021/pr0500105 . 10.1.1.706.313.
• Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM . Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid . Mol. Cell. Proteomics . 4 . 12 . 2000–9 . 2006 . 16199891 . 10.1074/mcp.M500207-MCP200 . free.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 1850943 . 10.1021/pr0502065.
• Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA . Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry . J. Proteome Res. . 5 . 6 . 1493–503 . 2006 . 16740002 . 10.1021/pr050492k.

Notes and References

1. Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM . Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family . J Biol Chem . 269 . 27 . 18149–54 . Aug 1994 . 10.1016/S0021-9258(17)32429-8 . 7517938 . free .
2. Web site: Entrez Gene: AFM afamin.