Ad Bax Explained

Adriaan (Ad) Bax
Birth Place:Netherlands
Fields:Nuclear magnetic resonance, biophysics
Workplaces:NIDDK, National Institutes of Health
Education:Delft University of Technology
Thesis Title:Two-Dimensional Nuclear Magnetic Resonance in Liquids
Thesis Year:1981
Doctoral Advisor:Ray Freeman and Toon Mehlkopf
Known For:Methods development for NMR, such as RDCs (Residual dipolar coupling)
Awards:Bijvoet Medal of the Bijvoet Center for Biomolecular Research (1993)E. Bright Wilson Award (2000)
National Academy of Sciences (2002)
American Academy of Arts and Sciences (2002)
Welch Award in Chemistry (2018)
NAS Award for Scientific Reviewing (2018)
Foreign Member of the Royal Society (2024)

Adriaan "Ad" Bax (born 1956) is a Dutch-American molecular biophysicist. He was born in the Netherlands and is the Chief of the Section on Biophysical NMR Spectroscopy at the National Institutes of Health. He is known for his work on the methodology of biomolecular NMR spectroscopy. He is a corresponding member of the Royal Netherlands Academy of Arts and Sciences, a member of the National Academy of Sciences, a fellow of the American Academy of Arts and Sciences, and a Foreign Member of the Royal Society.

Biography

Bax was born in the Netherlands. He studied at Delft University of Technology where he got his engineer's degree (Ir. degree) in 1978, and Ph.D. degree in applied physics in 1981, after spending considerable time working with Ray Freeman at Oxford University. He worked as a postdoc with Gary Maciel at Colorado State University, before joining the NIH's Laboratory of Chemical Physics in 1983. In 1994 he became correspondent of the Royal Netherlands Academy of Arts and Sciences.[1] He is currently the Chief of the Section on Biophysical NMR Spectroscopy at NIH. In 2002 he was elected a member of the National Academy of Sciences in the section on Biophysics and computational biology and a Fellow of the American Academy of Arts and Sciences.[2] Bax was awarded the 2018 NAS Award for Scientific Reviewing and the 2018 Welch Award in Chemistry.[3] He was elected as a foreign member of the Royal Society in 2024.[4]

Work in NMR spectroscopy

Bax works in the field of biomolecular NMR spectroscopy, and has been involved in the development of many of the standard methods in the field. He collaborated extensively with fellow NIH scientists Marius Clore, Angela Gronenborn and Dennis Torchia in the development of multidimensional protein NMR.[5] Bax is a pioneer in the development of triple resonance experiments and technology for resonance assignment of isotopically enriched proteins.[6] [7] He was also heavily involved in the development of using residual dipolar couplings[8] and chemical shifts[9] for determining RNA[10] and protein structures.[11] Much of his recent work focuses on the roles of proteins in membranes.[12] [13] [14] He was the world's most cited chemist over two decades (1981-1997).[15] [16]

Work during COVID-19 pandemic

Using laser light scattering, Bax examined how speech-generated droplets and aerosols may be a dominant SARS-CoV-2 transmission mode that may be mitigated by wearing face coverings or face masks.[17] [18]

External links

Notes and References

  1. Web site: A. Bax . . 18 July 2015 . 21 July 2015 . https://web.archive.org/web/20150721201905/https://www.knaw.nl/en/members/correspondents/3840 . dead .
  2. Web site: Book of Members, 1780-2010: Chapter B. American Academy of Arts and Sciences. May 28, 2011.
  3. Web site: Welch Award in Chemistry . www.welch1.org.
  4. Web site: Outstanding scientists elected as Fellows of the Royal Society Royal Society . 2024-05-19 . royalsociety.org . en.
  5. Book: Clore. Marius G. Encyclopedia of Magnetic Resonance. 2011. John Wiley & Sons. 9780470034590. http://spin.niddk.nih.gov/clore/Pub/pdf/432.pdf. Adventures in Biomolecular NMR. 10.1002/9780470034590. 11693/53364. Harris. Robin K. Wasylishen. Roderick L.
  6. Ikura M . Kay LE . Bax A . A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin. . Biochemistry . 29 . 19 . 4659–67 . 1990 . 2372549 . 10.1021/bi00471a022.
  7. Lewis E Kay . Mitsuhiko Ikura . Rolf Tschudin, Ad Bax . Three-dimensional triple-resonance NMR spectroscopy of isotopically enriched proteins . Journal of Magnetic Resonance . 89 . 3 . 496–514 . 1990 . 10.1016/0022-2364(90)90333-5. 1990JMagR..89..496K .
  8. Tjandra N . Grzesiek S . Bax A . Journal of the American Chemical Society . 118 . 26 . 6264–6272 . 1996 . Magnetic field dependence of nitrogen-proton J splittings in 15N-enriched human ubiquitin resulting from relaxation interference and residual dipolar coupling . 10.1021/ja960106n.
  9. Book: Kontaxis G . Delaglio F . Bax A . Molecular Fragment Replacement Approach to Protein Structure Determination by Chemical Shift and Dipolar Homology Database Mining . Nuclear Magnetic Resonance of Biological Macromolecules . Methods in Enzymology . 394 . 42–78 . 2005 . 10.1016/s0076-6879(05)94003-2. 15808217 . 9780121827991 .
  10. Boisbouvier A . Delaglio F . Bax A . Direct observation of dipolar couplings between distant protons in weakly aligned nucleic acids . Proceedings of the National Academy of Sciences of the United States of America . 100 . 20 . 11333–11338 . 2003 . 10.1073/pnas.1534664100. 2003PNAS..10011333B . 12972645 . 208757. free .
  11. Bax A . Grishaev A . Weak alignment NMR: a hawk-eyed view of biomolecular structure . Curr. Opin. Struct. Biol. . 15 . 5 . 563–70 . October 2005. 16140525 . 10.1016/j.sbi.2005.08.006 .
  12. Maltsev AS . Chen J . Levine RL. Bax A . Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates . J. Am. Chem. Soc. . 135 . 8 . 2943–6 . February 2013. 23398174 . 3585462 . 10.1021/ja312415q.
  13. Lorieau JL . Louis JM . Bax A . The impact of influenza hemagglutinin fusion peptide length and viral subtype on its structure and dynamics . Biopolymers . 99 . 3 . 189–95 . March 2013. 23015412 . 10.1002/bip.22102 . 3532579.
  14. Lakomek NA . Kaufman JD . Stahl SJ . Louis JM . Grishaev A . Wingfield PT . Bax A . Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales . Angew. Chem. Int. Ed. Engl. . 52 . 14 . 3911–5 . April 2013. 23450638 . 10.1002/anie.201207266 . 3610801.
  15. Web site: Citation Laureates: Chemistry . https://web.archive.org/web/20021102021041/http://in-cites.com/nobel/2002-nobel-chemistry.html . 2 November 2002 . In Cites . dead.
  16. Web site: 50 Most Cited Chemists 1981-1997 . pcb4122.univ-lemans.fr . 12 January 2022 . https://web.archive.org/web/20030301122315/http://pcb4122.univ-lemans.fr/citation.html . 1 March 2003 . dead.
  17. Anfinrud. Philip. Stadnytskyi. Valentyn. Bax. Christina E.. Bax. Adriaan. 2020-05-21. Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering. New England Journal of Medicine. 382. 21. 2061–2063. 10.1056/nejmc2007800. 32294341. 7179962. 0028-4793. free.
  18. Stadnytskyi. Valentyn. Bax. Christina E.. Bax. Adriaan. Anfinrud. Philip. 2020-06-02. The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proceedings of the National Academy of Sciences. en. 117. 22. 11875–11877. 10.1073/pnas.2006874117. 0027-8424. 7275719. 32404416. 2020PNAS..11711875S . free.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ad Bax".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.