Adrenodoxin-NADP+ reductase explained

Adrenodoxin-NADP^+ reductase
Ec Number:	1.18.1.6

Adrenodoxin-NADP⁺ reductase (adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP⁺ oxidoreductase.^{[1] [2] [3] [4] [5] [6] [7]} This enzyme catalyses the following chemical reaction

2 reduced adrenodoxin + NADP⁺

\rightleftharpoons 2 oxidized adrenodoxin + NADPH + H⁺

Adrenodoxin-NADP+ reductase is a flavoprotein (FAD).

Notes and References

1. Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase . Omura T, Sanders E, Estabrook RW, Cooper DY, Rosenthal O . Arch. Biochem. Biophys. . 1966 . 117 . 3 . 660–673 . 10.1016/0003-9861(66)90108-1.
2. Chu JW, Kimura T . Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein) . The Journal of Biological Chemistry . 248 . 6 . 2089–94 . March 1973 . 4144106 .
3. Sugiyama T, Yamano T . Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria . FEBS Letters . 52 . 1 . 145–8 . March 1975 . 235468 . 10.1016/0014-5793(75)80658-2 .
4. Hanukoglu I, Jefcoate CR . Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin . The Journal of Biological Chemistry . 255 . 7 . 3057–61 . April 1980 . 6766943 .
5. Hanukoglu I, Hanukoglu Z . Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation . European Journal of Biochemistry . 157 . 1 . 27–31 . May 1986 . 3011431 . 10.1111/j.1432-1033.1986.tb09633.x . free .
6. Hanukoglu I, Gutfinger T . cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases . European Journal of Biochemistry . 180 . 2 . 479–84 . March 1989 . 2924777 . 10.1111/j.1432-1033.1989.tb14671.x . free .
7. Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE . The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis . Journal of Molecular Biology . 289 . 4 . 981–90 . June 1999 . 10369776 . 10.1006/jmbi.1999.2807 .