Adrenal androgen-stimulating hormone explained

Adrenal androgen stimulating hormone (AASH), also known as cortical androgen stimulating hormone (CASH), is a hypothetical hormone which has been proposed to stimulate the adrenal glands to produce adrenal androgens such as dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4).^{[1] [2]} It is hypothesized to be involved in adrenarche and adrenopause. The existence of this hormone is controversial and disputed and it has not been identified to date. A number of other mechanisms and/or hormones may instead play the functional role of the so-called AASH.^[3]

See also

• Adrenocorticotrophic hormone (ACTH)

Notes and References

1. Anderson DC . The adrenal androgen-stimulating hormone does not exist . Lancet . 2 . 8192 . 454–6 . August 1980 . 6106101 . 10.1016/s0140-6736(80)91889-9 .
2. Alesci S, Bornstein SR . Intraadrenal mechanisms of DHEA regulation: a hypothesis for adrenopause . Exp Clin Endocrinol Diabetes . 109 . 2 . 75–82 . 2001 . 11341302 . 10.1055/s-2001-14826 .
3. Parker LN . Control of adrenal androgen secretion . Endocrinol Metab Clin North Am . 20 . 2 . 401–21 . June 1991 . 1652437 . 10.1016/S0889-8529(18)30275-5 .