Adozelesin Explained

Adozelesin is an experimental antitumor drug of the duocarmycin class.[1] It binds to and alkylates DNA, resulting in a reduction of both cellular and simian virus 40 (SV40) DNA replication which ultimately reduces the rate of cancer growth.[2]

Notes and References

  1. 11325853. 2001. Wang. Y. Beerman. TA. Kowalski. D. Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants. 61. 9. 3787–94. Cancer Research.
  2. Liu. J.-S.. Kuo. S.-R.. McHugh. M. M.. Beerman. T. A.. Melendy. T.. Adozelesin Triggers DNA Damage Response Pathways and Arrests SV40 DNA Replication through Replication Protein A Inactivation. Journal of Biological Chemistry. 14 January 2000. 275. 2. 1391–1397. 10.1074/jbc.275.2.1391. free. 10625690 .

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