Adiponectin receptor 1 explained

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.^[1] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.^[2]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[1]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^{[1] [3]} In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.^[4]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355^[5]
• ADP-399

Non-peptide

• AdipoRon^[6]
• (−)-Arctigenin^[7]
• Arctiin
• Gramine
• Matairesinol

Antagonists

Peptide

• ADP-400

See also

• Adiponectin receptor
• Adiponectin receptor 2

Further reading

• Crimmins NA, Martin LJ . Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance . Obesity Reviews . 8 . 5 . 419–23 . September 2007 . 17716299 . 10.1111/j.1467-789X.2007.00348.x . 825474 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Research . 10 . 5 . 703–13 . May 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
• Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T . Cloning of adiponectin receptors that mediate antidiabetic metabolic effects . Nature . 423 . 6941 . 762–9 . June 2003 . 12802337 . 10.1038/nature01705 . 2003Natur.423..762Y . 52860797 .
• Kharroubi I, Rasschaert J, Eizirik DL, Cnop M . Expression of adiponectin receptors in pancreatic beta cells . Biochemical and Biophysical Research Communications . 312 . 4 . 1118–22 . December 2003 . 14651988 . 10.1016/j.bbrc.2003.11.042 .
• Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E . Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes . Diabetologia . 47 . 5 . 816–20 . May 2004 . 15105989 . 10.1007/s00125-004-1359-x . free .
• Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, Elbein SC . Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance . Diabetes . 53 . 8 . 2132–6 . August 2004 . 15277397 . 10.2337/diabetes.53.8.2132 . free .
• Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Péterfi C, Weisser M, Machicao F, Stumvoll M, Häring HU . Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism . Diabetes . 53 . 9 . 2195–201 . September 2004 . 15331527 . 10.2337/diabetes.53.9.2195 . free .
• Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE . Adiponectin and its receptors are expressed in bone-forming cells . Bone . 35 . 4 . 842–9 . October 2004 . 15454091 . 10.1016/j.bone.2004.06.008 .
• Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, Keizer HA, Cameron-Smith D, van Loon LJ . The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle . European Journal of Endocrinology. 152 . 3 . 427–36 . March 2005 . 15757860 . 10.1530/eje.1.01872 . free . 10536/DRO/DU:30008881 . free .
• Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T . Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes . Diabetologia . 48 . 7 . 1307–14 . July 2005 . 15918014 . 10.1007/s00125-005-1806-3 . free .
• Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR . Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish . Diabetes . 54 . 7 . 2245–50 . July 2005 . 15983228 . 10.2337/diabetes.54.7.2245 . free .
• Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, Schölmerich J, Buechler C . Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors . Biochemical and Biophysical Research Communications . 334 . 3 . 924–9 . September 2005 . 16023994 . 10.1016/j.bbrc.2005.06.187 .
• Zhang J, Holt H, Wang C, Hadid OH, Byrne CD . Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men . Diabetes Care . 28 . 8 . 2058–60 . August 2005 . 16043761 . 10.2337/diacare.28.8.2058 . free .
• Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD . PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif . Journal of Molecular Evolution . 61 . 3 . 372–80 . September 2005 . 16044242 . 10.1007/s00239-004-0375-2 . 2005JMolE..61..372T . 31473802 .
• Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, Powell EE, Tilg H . Adiponectin and its receptors in patients with chronic hepatitis C . Journal of Hepatology . 43 . 6 . 929–36 . December 2005 . 16139921 . 10.1016/j.jhep.2005.05.030 .

Notes and References

1. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T . Cloning of adiponectin receptors that mediate antidiabetic metabolic effects . Nature . 423 . 6941 . 762–9 . June 2003 . 12802337 . 10.1038/nature01705 . 2003Natur.423..762Y . 52860797 .
2. Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD . PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif . Journal of Molecular Evolution . 61 . 3 . 372–80 . September 2005 . 16044242 . 10.1007/s00239-004-0375-2 . 2005JMolE..61..372T . 31473802 .
3. Web site: Entrez Gene: ADIPOR1 adiponectin receptor 1.
4. https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups
5. Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S . Development of second generation peptides modulating cellular adiponectin receptor responses . Frontiers in Chemistry . 2 . 93 . 2014 . 25368867 . 4201147 . 10.3389/fchem.2014.00093 . 2014FrCh....2...93O . free .
6. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T . A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity . Nature . 503 . 7477 . 493–9 . November 2013 . 24172895 . 10.1038/nature12656 . 2013Natur.503..493O . 4447039 .
7. Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z . Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay . PLOS ONE . 8 . 5 . e63354 . 2013 . 23691032 . 3653934 . 10.1371/journal.pone.0063354 . 2013PLoSO...863354S . free .