Adipocyte protein 2 explained

aP2 (adipocyte Protein 2)^[1] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs^[2] has the possibility of treating heart disease and the metabolic syndrome.^[3]

See also

• Fatty acid-binding protein

External links

• • • PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte

Notes and References

1. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA . Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA . Biochemistry . 28 . 22 . 8683–90 . 1989 . 2481498 . 10.1021/bi00448a003 .
2. Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A . Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review . European Journal of Medicinal Chemistry . 138 . 854–873 . September 2017 . 28738306 . 10.1016/j.ejmech.2017.07.022 .
3. Furuhashi M . Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases . Journal of Atherosclerosis and Thrombosis. 26 . 3 . 216–232 . March 2019 . 30726793. 6402888 . 10.5551/jat.48710 . Review .