Adhesion molecule (immunoglobulin-like) explained

Symbol:	Adhes-Ig_like
Adhes-Ig_like
Pfam:	PF09085
Pfam Clan:	CL0159
Interpro:	IPR015169
Scop:	1gsm

In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins.^[1] The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.^{[1] [2]}

See also

• Bacterial adhesin
• Cell adhesion
• Fungal adhesin

Notes and References

1. Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH . The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition . Structure . 6 . 6 . 793–801 . June 1998. 9655832 . 10.1016/S0969-2126(98)00080-X. free .
2. Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL . A reassessment of the MAdCAM-1 structure and its role in integrin recognition . Acta Crystallogr. D . 58 . Pt 2 . 233–41 . February 2002. 11807247 . 10.1107/S0907444901020522.