Adenosine 5'-tetraphosphate explained

Adenosine 5′-tetraphosphate, Ap4 or ATPP is a nucleotide. It is produced from ATP and triphosphate (P3) through the action of acetyl—CoA synthetase.[1] Acetyl—CoA synthetase also produces adenosine 5'-pentaphosphate through the reaction of ADP and tetraphosphate (P4).

Functions

ATPP has been found to play physiological roles in some mammals.

Rabbits

ATPP is a constituent of aqueous humor in rabbits, where it was found to reduce the intraocular pressure.[2]

Rats

ATPP has been suggested to play a regulatory role in rat aorta.

Notes and References

  1. Guranowski, A.. Günther Sillero, M.A.. Sillero, A.. Adenosine 5′-tetraphosphate and adenosine 5′-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase.. J Bacteriol . 1994 . 176 . 10 . 2986–90 . 7910605 . 10.1128/jb.176.10.2986-2990.1994. 205455 .
  2. Pintor. Jesús. Peláez. Teresa. Peral. Assumpta. February 2004. Adenosine tetraphosphate, Ap4, a physiological regulator of intraocular pressure in normotensive rabbit eyes. The Journal of Pharmacology and Experimental Therapeutics. 308. 2. 468–473. 10.1124/jpet.103.058669. 0022-3565. 14600249. 27129583.

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