Adenosine receptor antagonist explained

An adenosine receptor antagonist is a drug which acts as an antagonist of one or more of the adenosine receptors.[1] The best known are xanthines and their derivatives (natural: caffeine,[2] theophylline,[3] and theobromine; and synthetic: PSB-1901[4]), but there are also non-xanthine representatives (e.g. ISAM-140,[5] ISAM-R316,[6] Etrumadenant, and AZD-4635[7])

See also

Notes and References

  1. Book: Müller. CE. Jacobson. KA. Xanthines as adenosine receptor antagonists.. Handbook of Experimental Pharmacology. 2011. 200. 200. 151–99. 20859796. 10.1007/978-3-642-13443-2_6. 3882893. 978-3-642-13442-5.
  2. Rivera-Oliver. Marla. Díaz-Ríos. Manuel. Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review. Life Sciences. April 2014. 101. 1–2. 1–9. 10.1016/j.lfs.2014.01.083. 24530739. 4115368.
  3. Hauber. W.. Muenkle. M.. The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists. Naunyn-Schmiedeberg's Archives of Pharmacology. July 1996. 354. 2. 179–186. 10.1007/BF00178718. 8857595. 21765941 .
  4. Jiang . Jie . Seel . Catharina Julia . Temirak . Ahmed . Namasivayam . Vigneshwaran . Arridu . Antonella . Schabikowski . Jakub . Baqi . Younis . Hinz . Sonja . Hockemeyer . Jörg . Müller . Christa E. . 2019-04-25 . A2B Adenosine Receptor Antagonists with Picomolar Potency . Journal of Medicinal Chemistry . 62 . 8 . 4032–4055 . 10.1021/acs.jmedchem.9b00071 . 1520-4804 . 30835463. 73472174 .
  5. El Maatougui . Abdelaziz . Azuaje . Jhonny . González-Gómez . Manuel . Miguez . Gabriel . Crespo . Abel . Carbajales . Carlos . Escalante . Luz . García-Mera . Xerardo . Gutiérrez-de-Terán . Hugo . Sotelo . Eddy . 2016-03-10 . Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes . Journal of Medicinal Chemistry . 59 . 5 . 1967–1983 . 10.1021/acs.jmedchem.5b01586 . 1520-4804 . 26824742.
  6. Prieto-Díaz . Rubén . González-Gómez . Manuel . Fojo-Carballo . Hugo . Azuaje . Jhonny . El Maatougui . Abdelaziz . Majellaro . Maria . Loza . María I. . Brea . José . Fernández-Dueñas . Víctor . Paleo . M. Rita . Díaz-Holguín . Alejandro . Garcia-Pinel . Beatriz . Mallo-Abreu . Ana . Estévez . Juan C. . Andújar-Arias . Antonio . 2022-12-14 . Exploring the Effect of Halogenation in a Series of Potent and Selective A 2B Adenosine Receptor Antagonists . Journal of Medicinal Chemistry . 66 . 1 . en . 890–912 . 10.1021/acs.jmedchem.2c01768 . 36517209 . 9841532 . 254759241 . 0022-2623.
  7. Borodovsky . Alexandra . Barbon . Christine M. . Wang . Yanjun . Ye . Minwei . Prickett . Laura . Chandra . Dinesh . Shaw . Joseph . Deng . Nanhua . Sachsenmeier . Kris . Clarke . James D. . Linghu . Bolan . Brown . Giles A. . Brown . James . Congreve . Miles . Cheng . Robert Ky . July 2020 . Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity . Journal for Immunotherapy of Cancer . 8 . 2 . e000417 . 10.1136/jitc-2019-000417 . 2051-1426 . 7394305 . 32727810.

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