Adenain Explained

Adenain
Ec Number:	3.4.22.39
Cas Number:	369652-03-9

Adenain is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-Xaa- and -Yaa-Xaa-Gly-Xaa-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid)

This cysteine endopeptidase is encoded by adenoviruses.

Notes and References

1. Webster A, Hay RT, Kemp G . The adenovirus protease is activated by a virus-coded disulphide-linked peptide . Cell . 72 . 1 . 97–104 . January 1993 . 8422686 . 10.1016/0092-8674(93)90053-s .
2. Ding J, McGrath WJ, Sweet RM, Mangel WF . Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor . The EMBO Journal . 15 . 8 . 1778–83 . April 1996 . 8617222 . 450093 .
3. Book: Adenovirus protease . Handbook of Proteolytic Enzymes . Weber, J.M. . 1998 . 741–743 . Barrett, A.J. . Rawlings, N.D. . Woessner, J.F. . Academic Press . London .