Adamantyl-THPINACA explained

Adamantyl-THPINACA (ATHPINACA, AD-THPINACA)^[1] is an indazole-based synthetic cannabinoid,^[2] which was first reported to Europol in Slovenia in January 2015.^[3] It is known as both the 1-adamantyl and 2-adamantyl isomers (SGT-40 and SGT-194 respectively), which can be distinguished by GC-EI-MS.^[4] It is banned in Sweden^[5] and Russia.^[6] Both the 1-adamantyl and 2-adamantyl isomers are specifically listed as illegal drugs in Japan.^[7] Given the known metabolic liberation (and presence as an impurity) of amantadine in the related compound APINACA, it is suspected that metabolic hydrolysis of the amide group of Adamantyl-THPINACA may also release amantadine.

See also

• 5F-ADB
• 5F-AMB
• 5F-APICA
• AB-CHMINACA
• AB-FUBINACA
• AB-CHFUPYCA
• AB-PINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• APICA
• APINACA
• APP-FUBINACA
• CUMYL-THPINACA
• MDMB-CHMINACA
• MDMB-FUBINACA
• PX-3

Notes and References

1. Web site: ATHPINACA isomer 1 (CAS 1400742-48-4). Caymen Chemical. 29 April 2017. en.
2. Web site: Muuntohuumeiden esiintyvyys 2015 . Finnish Medicines Agency . 7 May 2015 . 10 March 2021.
3. http://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA
4. Asada A, Doi T, Tagami T, Takeda A, Sawabe Y . Isomeric discrimination of synthetic cannabinoids by GC-EI-MS: 1-adamantyl and 2-adamantyl isomers of N-adamantyl carboxamides . Drug Testing and Analysis . 9 . 3 . 378–388 . March 2017 . 27770510 . 10.1002/dta.2124 .
5. Web site: Fler ämnen föreslås bli klassade som narkotika eller hälsofarlig vara . Folkhälsomyndigheten . 24 July 2015.
6. http://www.consultant.ru/cons/cgi/online.cgi?req=doc&base=LAW&n=222059&fld=134&dst=100034,0 List of substances prohibited in the Russian Federation
7. http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf 指定薬物一覧