Adam Bogdanove Explained

Adam Bogdanove
Birth Date:	1964
Nationality:	American
Fields:	Plant Pathology, Bioengineering
Workplaces:	Cornell University, Boyce Thompson Institute
Alma Mater:	Yale University, Cornell University
Known For:	TAL effectors, Genome editing
Website:	https://pppmb.cals.cornell.edu/people/adam-bogdanove

Adam J. Bogdanove (born 1964) is a Professor of Plant Pathology at Cornell University.^[1] He is most notable for his central role in the development of TAL effector based DNA targeting reagents, following his discovery of TAL effector modularity with Matthew Moscou in 2009.^[2] Since, he has been a leader in the field, pioneering applications in genome editing and contributing one of the most widely used methods for designing custom TAL effectors using Golden Gate Cloning.^[3] Bogdanove is now widely recognized for revolutionizing the area of DNA targeting, along with scientists such as Jennifer Doudna and Emmanuelle Charpentier.

Education

Bogdanove earned his Bachelor of Science degree in Biology from Yale University in 1987, and his Ph.D. in Plant Pathology from Cornell University in 1997,^[4] going on to do postdoctoral work at Purdue University.

Research and career

Bogdanove began his academic career in 2000 at Iowa State University as one of the first faculty hires of the Plant Science Institute.^[5] It was there that he made the 2006 landmark discovery of how TAL effectors recognize target sequences. A significant portion of his work uncovered the mechanisms by which TAL effectors increase disease susceptibility by manipulating host gene expression. Further work has paved the way for genome editing technologies like CRISPR and their applications, which use modified proteins to induce targeted changes in plant and animal DNA sequences. In 2012, Bogdanove returned to his alma mater as a Professor in the Plant Pathology and Plant- Microbe Biology section at Cornell University.^[6] Bogdanove's present research focuses on the pathogen Xanthomonas oryzae and its interactions with species of rice.

Selected bibliography

• Bogdanove . Adam J. . Adam Bogdanove . Martin . G. B. . AvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomato . Proceedings of the National Academy of Sciences. 97 . 16 . 2000-08-01 . 10.1073/pnas.97.16.8836 . 8836–8840 . 3093542 . 10922043. 34020 . 2000PNAS...97.8836B . free .
• Martin. Gregory B. . Bogdanove . Adam J. . Adam Bogdanove . Sessa. Guido. Understanding the Functions of Plant Disease Resistance Proteins . Annual Review of Plant Biology. 54. 1. 2003. 23–61. 10.1146/annurev.arplant.54.031902.135035. 14502984 .
• Wise . Roger P. . Moscou . Matthew J. . Bogdanove . Adam J. . Adam Bogdanove . Whitham . Steven A. . Transcript Profiling in Host–Pathogen Interactions . Annual Review of Phytopathology. 45 . 1 . 2007-09-08 . 10.1146/annurev.phyto.45.011107.143944 . 329–369. 17480183 .
• Moscou . M. J. . Bogdanove . A. J. . A Simple Cipher Governs DNA Recognition by TAL Effectors . . 326 . 5959 . 2009-10-29 . 10.1126/science.1178817 . 1501 . 19933106 . 2009Sci...326.1501M . 6648530.
• Ryan . Robert P. . Vorhölter . Frank-Jörg . Potnis . Neha . Jones . Jeffrey B. . Van Sluys . Marie-Anne . Bogdanove . Adam J. . Adam Bogdanove . Dow . J. Maxwell . Pathogenomics of Xanthomonas: understanding bacterium–plant interactions . . 9 . 5 . 2011-04-11 . 10.1038/nrmicro2558 . 344–355 . 37510468 . 21478901.
• Cermak . Tomas . Doyle . Erin L. . Christian . Michelle . Wang . Li . Zhang . Yong . Schmidt . Clarice . Baller . Joshua A. . Somia . Nikunj V. . Bogdanove . Adam J. . Voytas . Daniel F. . Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting . . 39 . 12 . 2011-04-14 . 10.1093/nar/gkr218 . e82 . 21493687 . 2703718. 3130291 .
• Bogdanove . Adam J. . Voytas . D. F. . TAL Effectors: Customizable Proteins for DNA Targeting . Science . 333 . 6051 . 2011-09-29 . 10.1126/science.1204094 . 1843–1846 . 5175261 . 21960622. 2011Sci...333.1843B .
• Mak . A. N.-S. . Bradley . P. . Cernadas . R. A. . Bogdanove . A. J. . Stoddard . B. L. . The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target . Science . 335 . 6069 . 2012-01-05 . 10.1126/science.1216211 . 716–719 . 22223736 . 3427646 . 2012Sci...335..716M . 46816158.
• Doyle . Erin L. . Booher . Nicholas J. . Standage . Daniel S. . Voytas . Daniel F. . Brendel . Volker P. . VanDyk . John K. . Bogdanove . Adam J. . TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction . . 40 . W1 . 2012-06-12 . 10.1093/nar/gks608 . W117–W122 . 22693217 . 445132. 3394250 .

External links

• ResearcherID: ABE-6252-2020
• Google Scholar page: -nCwvkMAAAAJ
• ORCID: 0000-0003-1683-4117

Notes and References

1. Web site: People in PPPMB: Adam Bogdanove. Cornell University CALS. 12 April 2016.
2. Moscou MJ, Bogdanove AJ . A simple cipher governs DNA recognition by TAL effectors . Science . 326 . 5959 . 1501 . December 2009 . 19933106 . 10.1126/science.1178817 . 2009Sci...326.1501M. 6648530 .
3. Cermak . T. . Doyle . E. L. . Christian . M. . Wang . L. . Zhang . Y. . Schmidt . C. . Baller . J. A. . Somia . N. V. . Bogdanove . A. J. . Voytas . D. F. . Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting . 10.1093/nar/gkr218 . Nucleic Acids Research . 39 . 12 . e82 . 2011 . 21493687. 3130291 .
4. Web site: People in PPPMB: Adam Bogdanove. Cornell University CALS. 12 April 2016.
5. Web site: Plant pathologist and sustainable ag enthusiast. Iowa State University. Cornell University PPPMP. 13 October 2020.
6. Web site: Adam Bogdanove.