PARVA explained

Alpha-parvin is a protein that in humans is encoded by the PARVA gene.^{[1] [2]}

Members of the parvin family, including PARVA, PARVB and PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM]

Further reading

• Nikolopoulos SN, Turner CE . Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. . J. Cell Biol. . 151 . 7 . 1435–48 . 2001 . 11134073 . 10.1083/jcb.151.7.1435. 2150668 .
• Tu Y, Huang Y, Zhang Y, etal . A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. . J. Cell Biol. . 153 . 3 . 585–98 . 2001 . 11331308 . 10.1083/jcb.153.3.585. 2190577 .
• Nikolopoulos SN, Turner CE . Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. . J. Biol. Chem. . 277 . 2 . 1568–75 . 2002 . 11694518 . 10.1074/jbc.M108612200 . free .
• Korenbaum E, Olski TM, Noegel AA . Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. . Gene . 279 . 1 . 69–79 . 2002 . 11722847 . 10.1016/S0378-1119(01)00743-0 .
• Zhang Y, Chen K, Tu Y, etal . Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. . J. Cell Sci. . 115 . Pt 24 . 4777–86 . 2003 . 12432066 . 10.1242/jcs.00166 . 13630628 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV . Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. . Biochem. J. . 383 . Pt 2 . 237–48 . 2005 . 15242332 . 10.1042/BJ20040647 . 1134064 .
• Zhang Y, Chen K, Tu Y, Wu C . Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. . J. Biol. Chem. . 279 . 40 . 41695–705 . 2004 . 15284246 . 10.1074/jbc.M401563200 . free .
• Clarke DM, Brown MC, LaLonde DP, Turner CE . Phosphorylation of actopaxin regulates cell spreading and migration. . J. Cell Biol. . 166 . 6 . 901–12 . 2004 . 15353548 . 10.1083/jcb.200404024 . 2172128 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• LaLonde DP, Brown MC, Bouverat BP, Turner CE . Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. . J. Biol. Chem. . 280 . 22 . 21680–8 . 2005 . 15817463 . 10.1074/jbc.M500752200 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Olski TM, Noegel AA, Korenbaum E . Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily . J Cell Sci . 114 . Pt 3 . 525–38 . Feb 2001 . 10.1242/jcs.114.3.525 . 11171322 .
2. Web site: Entrez Gene: PARVA parvin, alpha.