Activin receptor explained

An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain.[1] [2] [3]

Types include:

Human proteins containing this domain

ACVR1

ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; BMPR1A; BMPR1B; BMPR2
  • TGFBR1;

    • Notes and References

    1. Wrana JL, Attisano L . Signal transduction by members of the transforming growth factor-beta superfamily . Cytokine Growth Factor Rev. . 7 . 4 . 327–339 . 1996 . 9023056 . 10.1016/S1359-6101(96)00042-1.
    2. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J . Mechanism of activation of the TGF-beta receptor . Nature . 370 . 6488 . 341–347 . 1994 . 8047140 . 10.1038/370341a0. 4344481 .
    3. Massague J, Weis-Garcia F . Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals . Cancer Surv. . 27 . 41–64 . 1996 . 8909794.

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