Actinorhodin Explained

Actinorhodin is a benzoisochromanequinone dimer polyketide antibiotic produced by Streptomyces coelicolor.[1] [2] The gene cluster responsible for actinorhodin production contains the biosynthetic enzymes and genes responsible for export of the antibiotic.[3] The antibiotic also has the effect of being a pH indicator due to its pH-dependent color change.[4]

Notes and References

  1. Magnolo SK, Leenutaphong DL, DeModena JA . Actinorhodin production by Streptomyces coelicolor and growth of Streptomyces lividans are improved by the expression of a bacterial hemoglobin . Bio/Technology . 9 . 5 . 473–6 . May 1991 . 1367312 . 10.1038/nbt0591-473. 21623645 . etal.
  2. Brian P, Riggle PJ, Santos RA, Champness WC . Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system . J. Bacteriol. . 178 . 11 . 3221–31 . June 1996 . 8655502 . 178074 . 10.1128/jb.178.11.3221-3231.1996.
  3. Tahlan. K. Ahn SK. Sing A. Bodnaruk TD. Willems AR. Davidson AR. Nodwell JR.. February 2007. Initiation of actinorhodin export in Streptomyces coelicolor. Molecular Microbiology. 63. 4. 951–961. 17338074. 10.1111/j.1365-2958.2006.05559.x. free.
  4. Bystrykh. LV. Fernández-Moreno MA. Herrema JK. Malpartida F. Hopwood DA. Dijkhuizen L. April 1996. Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2). Journal of Bacteriology. 178. 8. 2238–44. 10.1128/jb.178.8.2238-2244.1996. 8636024. 177931.

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