Actinonin Explained

Actinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity.[1]

Actiononin has been shown to inhibit the enzyme peptide deformylase, which is essential in bacteria.[2]

Notes and References

  1. Chen . D.Z. . Patel . D.V. . Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor . Biochemistry . 39 . 1256–62 . 2000 . 10.1021/bi992245y . 10684604 . 6.
  2. Yoon. Hye-Jin. Kim. Hye Lee. Lee. Soo-Kyoung. Kim. Hyun-Woo. Kim. Hyung-Wook. Lee. Jae Young. Mikami. Bunzo. Suh. Se Won. 2004. Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent. Proteins: Structure, Function, and Bioinformatics. en. 57. 3. 639–642. 10.1002/prot.20231. 15382235. 42929776. 1097-0134.

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