Acridone synthase explained
| acridone synthase |
| Ec Number: | 2.3.1.159 |
| Cas Number: | 99085-53-7 |
| Go Code: | 0050635 |
In enzymology, an acridone synthase is an enzyme that catalyzes the chemical reaction
3 malonyl-CoA + N-methylanthraniloyl-CoA
4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO
2Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.
References
- Baumert A, Maier W, Gröger D, Deutzmann R . 1994 . Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L . Z. Naturforsch. C . 49 . 26 - 32 . 8148006 . 1-2 .
- Maier W, Baumert A, Schumann B, Furukawa H, Gröger D . 1993 . Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures . . 32 . 3 . 691 - 698 . 10.1016/S0031-9422(00)95155-0 .
- Matern U . 1999 . Native acridone synthases I and II from Ruta graveolens L. form homodimers . FEBS Lett. . 448 . 135 - 40 . 10217426 . 10.1016/S0014-5793(99)00355-5 . Springob . K . Urbanke . C . Ernwein . C . Schröder . G . Schröder . J . Matern . U . 1 .
- Junghanns KT, Kneusel RE, Gröger D, Matern U . 1998 . Differential regulation and distribution of acridone synthase in Ruta graveolens . . 49 . 403 - 11 . 9747538 . 10.1016/S0031-9422(98)00104-6 . 2 .
