Acral necrosis explained

Differential:	bubonic plague

Acral necrosis is a symptom common in bubonic plague. The striking black discoloration of skin and tissue, primarily on the extremities ("acral"), is commonly thought to have given rise to the name "Black Death," associated both with the disease and the pandemic which occurred in the 14th century. The term in fact came from the figural sense of "black", that is ghastly, lugubrious or dreadful.^{[1] [2]}

Acral necrosis may be a symptom of other diseases too. It also has been observed as an adverse event related to a medical treatment.^{[3] [4]}

External links

• eMedicine site

Description and graphic photographs

Notes and References

1. Book: Antosia. Robert. Cahill. John D.. Handbook of Bioterrorism and Disaster Medicine. 2006. Springer Science & Business Media. 9780387328041. 110. 8 November 2017. en.
2. Book: Roy. Michael J.. Physician's Guide to Terrorist Attack. 2003. Springer Science & Business Media. 9781592596638. 92. 8 November 2017. en.
3. Khaddour . Karam . Singh . Veerpal . Shayuk . Maryna . 2019-05-14 . Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review . BMC Cancer . 19 . 1 . 449 . 10.1186/s12885-019-5661-x . 1471-2407 . 6518656 . 31088420 . free .
4. Reiser . M. . Bruns . C. . Hartmann . P. . Salzberger . B. . Diehl . V. . Fätkenheuer . G. . January 1998 . Raynaud's phenomenon and acral necrosis after chemotherapy for AIDS-related Kaposi's sarcoma . European Journal of Clinical Microbiology & Infectious Diseases. 17 . 1 . 58–60 . 10.1007/BF01584368 . 0934-9723 . 9512187. 20332412 .