| Official Name: | Acona, Mississippi |
| Pushpin Map: | Mississippi#USA |
| Pushpin Label: | Acona |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Mississippi |
| Subdivision Type2: | County |
| Subdivision Name2: | Holmes |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 354 |
| Coordinates: | 33.2717°N -90.0161°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 38923 |
| Area Code: | 662 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 666139 |
Acona is an unincorporated community located in Holmes County, Mississippi. Acona is located on Mississippi Highway 17 and is approximately 12miles north of Lexington and approximately 4miles south of Black Hawk.
Acona appears to be a name derived from the Choctaw language, but its meaning is uncertain.[1] Some sources say Acona is derived from a Native American word of exclamation, similar to "whoa!" in English.[2] A post office called Acona was established in 1852, and remained in operation until 1911.[3] Acona was once home to a stage coach stop, tanyard, cotton gin, and millinery store.[2]
The Acona Church, Cemetery, and School are listed on the National Register of Historic Places.[4]