Acetylpyrazine Explained

Acetylpyrazine is an organic compound with the chemical formula . It is a yellow-brown powder at room temperature. Chemically, acetylpyrazine is a pyrazine and a ketone.

Natural occurrence

Acetylpyrazine is found in foods such as seeds, nuts and meats.

Uses

It is used in frozen dairy products such as ice cream.

It is considered generally recognized as safe by the U.S. Food and Drug Administration.^[1]

"Essence formula for increasing cigarette fragrance and improving smoke quality".^[2]

It is also known to be part of the formulation of e-cigarettes (vapes):^[3]

Synthesis

Note that modern synthesis is for 2-cyanopyrazine from 2-methylpyrazine [109-08-0].^{[4] [5]} Pyrazinamide [98-96-4] (1)2-Cyanopyrazine [19847-12-2] (2)

More modern syntheses have also been reported in recent years:^{[6] [7] [8]}

Notes and References

1. Web site: Martin, Terry . Acetylpyrazine . About.com Smoking Cessation . 8 Feb 2004 . 16 June 2014 . 6 January 2016 . https://web.archive.org/web/20160106202734/http://quitsmoking.about.com/cs/nicotineinhaler/g/term_8add.htm . dead .
2. Mao Deshou, et al. CN115216363 (2022 to China Tobacco Yunnan Industrial Co Ltd).
3. Book: Public Health Consequences of E-Cigarettes . 2018 . 10.17226/24952 . 29894118 . 978-0-309-46834-3 . en . NAP.edu . Stratton . Kwan . Eaton . Kathleen . Leslie Y. . David L. . National Academies of Sciences, Engineering, and Medicine . Health And Medicine . Division . Board on Population Health and Public Health Practice . Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems . Eaton . D. L. . Kwan . L. Y. . Stratton . K. .
4. Rao . K. Narasimha . Gopinath . Rajesh . Prasad . P. S. Sai . 2001 . Highly selective molybdenum phosphate catalyst for the ammoxidation of 2-methylpyrazine to 2-cyanopyrazine . Green Chemistry . 3 . 1 . 20–22 . 10.1039/b005643j.
5. Hong . Chun . Li . Yong . 2006 . 2-Cyanopyrazine Prepared from 2-Methylpyrazine by Catalytic Ammoxidation on MoVPO Catalyst . Chinese Journal of Chemical Engineering . en . 14 . 5 . 670–675 . 10.1016/S1004-9541(06)60133-X.
6. Mao . Lin . Niu . Dong-Fang . Hu . Shuo-Zhen . Zhang . Xin-Sheng . 2022-05-28 . Electrochemical Synthesis of Acetylpyrazine . Journal of Electrochemistry . en . 28 . 5 . 2107061 . 10.13208/j.electrochem.210706.
7. Wang et al.: Progress in the Synthesis and Application of Acetylpyrazine, 2011.
8. 任伟, et al. CN106588785 (2017 to Yoshida Spice Ltd By Share Ltd Shandong).