Acetryptine Explained

Acetryptine (INN) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT),^[1] is a drug described as an antihypertensive agent which was never marketed.^[2] Structurally, acetryptine is a substituted tryptamine, and is closely related to other substituted tryptamines like serotonin (5-hydroxytryptamine). It was developed in the early 1960s. The binding of acetryptine to serotonin receptors does not seem to have been well-investigated, although it was assessed at the 5-HT_1A and 5-HT_1D receptors and found to bind to them with high affinity.^[3] The drug may also act as a monoamine oxidase inhibitor (MAOI); specifically, as an inhibitor of MAO-A.^{[4] [5]}

See also

• 5-Benzyloxytryptamine
• 5-Carboxamidotryptamine
• 5-Ethoxy-DMT
• 5-Methoxytryptamine
• 5-(Nonyloxy)tryptamine
• Azepindole
• Indorenate
• Metralindole
• Pargyline
• Pirlindole
• Sumatriptan
• Tetrindole

Notes and References

1. HARTIGAN JM, PHILLIPS GE . Tissue distribution and metabolism of 5-acetyltryptamine in the mouse . Biochem. Pharmacol. . 12 . 6. 585–8 . 1963 . 13953098 . 10.1016/0006-2952(63)90136-9.
2. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 6–.
3. Glennon RA, Hong SS, Bondarev M, Law H, Dukat M, Rakhi S, Power P, Fan E, Kinneau D, Kamboj R, Teitler M, Herrick-Davis K, Smith C . Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors . J. Med. Chem. . 39 . 1 . 314–22 . 1996 . 8568822 . 10.1021/jm950498t .
4. Veselovsky AV, Medvedev AE, Tikhonova OV, Skvortsov VS, Ivanov AS . Modeling of substrate-binding region of the active site of monoamine oxidase A . Biochemistry Mosc. . 65 . 8 . 910–6 . 2000 . 11002183 .
5. Ramsay RR, Gravestock MB . Monoamine oxidases: to inhibit or not to inhibit . Mini Rev Med Chem . 3 . 2 . 129–36 . 2003 . 12570845 . 10.2174/1389557033405287.