Acetoacetyl-CoA synthase explained

Acetoacetyl-CoA synthase
Ec Number:	2.3.1.194

Acetoacetyl-CoA synthase (NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating).^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons acetoacetyl-CoA + CoA + CO₂

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA.

Notes and References

1. Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T . Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway . Proceedings of the National Academy of Sciences of the United States of America . 107 . 25 . 11265–70 . June 2010 . 20534558 . 2895072 . 10.1073/pnas.1000532107 . free .