| Acetate—CoA ligase (ADP-forming) | |
| Ec Number: | 6.2.1.13 |
| Cas Number: | 62009-85-2 |
| Go Code: | 0043758 |
| Width: | 270 |
In enzymology, an acetate—CoA ligase (ADP-forming) is an enzyme that catalyzes the chemical reaction
ATP + acetate + CoA
\rightleftharpoons
The 3 substrates of this enzyme are ATP, acetate, and CoA, whereas its 3 products are ADP, phosphate, and acetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetate:CoA ligase (ADP-forming). Other names in common use include acetyl-CoA synthetase (ADP-forming), acetyl coenzyme A synthetase (adenosine diphosphate-forming), and acetate thiokinase. This enzyme participates in pyruvate metabolism and propanoate metabolism.