Aceglutamide Explained

Aceglutamide (brand name Neuramina), or aceglutamide aluminium (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan.[1] [2] [3] [4] It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain.[5] Aceglutamide functions as a prodrug to glutamine with improved potency and stability.

Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminium is used in the treatment of ulcers.[6] [7] [8] [9] Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition.[10] [11] [12] The drug has shown neuroprotective effects in an animal model of cerebral ischemia.

See also

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 3–.
  2. Book: Index Nominum 2000: International Drug Directory. January 2000. Taylor & Francis. 978-3-88763-075-1. 6–.
  3. Book: William Andrew Publishing. Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. 22 October 2013. Elsevier. 978-0-8155-1856-3. 35–.
  4. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 3–.
  5. Zhang R, Yang N, Ji C, Zheng J, Liang Z, Hou CY, Liu YY, Zuo PP . 6 . Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion . Restorative Neurology and Neuroscience . 33 . 5 . 741–59 . 2015 . 26444640 . 10.3233/RNN-150509 .
  6. Ito M, Yokochi E, Kobayashi C, Suzuki Y . [Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminium on defensive factors in acetic acid ulcers of rats (author's transl)] . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica . 79 . 4 . 327–34 . April 1982 . 7095654 . 10.1254/fpj.79.327 . free .
  7. Inhibitory effect of N-acetyl-L-glutamine aluminium complex (KW-110) and related compounds on gastric erosion and motility in stressed animals . Harada M, Yano S . Oyo Yakuri . 1974 . 8 . 1 . 1–6.
  8. Varas Lorenzo MJ, López Martínez A, Gordillo Bernal J, Mundet Surroca J . [Comparative study of 3 drugs (aceglutamide aluminium, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer] . Revista Espanola de Enfermedades Digestivas . 80 . 2 . 91–4 . August 1991 . 1790087 .
  9. Tanaka H, Shuto K, Marumo H . Effect of N-acetyl-L-glutamine aluminium complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats . Japanese Journal of Pharmacology . 32 . 2 . 307–13 . April 1982 . 7098147 . 10.1254/jjp.32.307 . free .
  10. López-Pedrosa JM, Manzano M, Baxter JH, Rueda R . N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs . Digestive Diseases and Sciences . 52 . 3 . 650–8 . March 2007 . 17253138 . 10.1007/s10620-006-9500-y . 37484555 .
  11. JP. H10101576. 1998-04-21. Treating medicine for digestive organ disease. Nisshin Flour Milling Co Ltd.. Sasaki. Kazuyuki. Hayakawa. Toru.
  12. US. 2003099722. application. 2003-05-29. Methods and compositions for providing glutamine. Abbott Laboratories. Baxter. Jeffrey., abandoned during patent examination

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Aceglutamide".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.