Aceclidine Explained

Aceclidine (Glaucostat, Glaunorm, Glaudin) is a parasympathomimetic miotic agent used in the treatment of narrow angle glaucoma.

Medicinal properties

Aceclidine decreases intraocular pressure. It acts as a muscarinic acetylcholine receptor agonist.^[1]

Side effects of aceclidine include increased salivation and bradycardia (in excessive doses).

Chemistry

Aceclidine is an organic compound that is structurally related to quinuclidine. As such its alternative name is 3-acetoxyquinuclidine. Its protonated derivative has a pKa of 9.3.^[2]

See also

• Talsaclidine (drug with a similar structure)
• Muscarine

Notes and References

1. Shannon HE, Hart JC, Bymaster FP, Calligaro DO, DeLapp NW, Mitch CH, Ward JS, Fink-Jensen A, Sauerberg P, Jeppesen L, Sheardown MJ, Swedberg MD . 6 . Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats . The Journal of Pharmacology and Experimental Therapeutics . 290 . 2 . 901–907 . August 1999 . 10411607 .
2. Aggarwal VK, Emme I, Fulford SY . Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope . The Journal of Organic Chemistry . 68 . 3 . 692–700 . February 2003 . 12558387 . 10.1021/jo026671s .