| AbdulHusain Husamuddin | |
| Native Name: | عَبدُالحُسَين حُسامُ الدِين |
| Birth Date: | 10th Muharram al-Haram 1239 AH/1823 AD |
| Death Date: | 27th Zilhijjat al-Haram 1308 AH/1891 AD |
| Resting Place: | Mazar-e-Qutbi, Ahmedabad, India |
| Religion: | Shi'a Islam |
| Sect: | Ismailism |
| Subsect: | Dawoodi Bohra |
| Predecessor1: | Abdul Qadir Najmuddin |
| Successor1: | Mohammed Burhanuddin I |
| Background: |
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| Office1: | Da'i al-Mutlaq |
| Term Start1: | 1885 |
| Term End1: | 1891 |
Syedna AbdulHusain Husamuddin bin Syedna Tayyeb Zainuddin was the 48th Da'i al-Mutlaq of the Dawoodi Bohra. He was born on the day of Ashura (10th Muharram al-Haram) in 1239 AH/1823 AD and died on 27th Zilhijjat al-Haram 1308 AH/1891 AD in Ahmedabad, India.
He succeeded his brother, the 47th Da'i, Syedna AbdulQadir Najmuddin, to the religious post. Syedna Husamuddin became Da'i al-Mutlaq in 1302 AH/1885 AD.[1] His period of Dawat was 1302–1308 AH/1885–1891 AD.[2] [3] Syedna Abdul Husain Husamuddin appointed or gave nass to Syedna Mohammad Burhanuddin (49th Dai) as his successor.[4]