AZIN2 explained

Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene.^{[1] [2] [3]} In contrast to initial suggestions,^[4] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells ^{[5] [6]}

Further reading

• Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Research . 8 . 6 . 319–327 . December 2001 . 11853319 . 10.1093/dnares/8.6.319 . free .
• Coleman CS, Hu G, Pegg AE . Putrescine biosynthesis in mammalian tissues . The Biochemical Journal . 379 . Pt 3 . 849–855 . May 2004 . 14763899 . 1224126 . 10.1042/BJ20040035 .
• Choi KS, Suh YH, Kim WH, Lee TH, Jung MH . Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity . Biochemical and Biophysical Research Communications . 328 . 1 . 206–212 . March 2005 . 15670771 . 10.1016/j.bbrc.2004.11.172 .
• López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R . Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity . The Journal of Biological Chemistry . 281 . 41 . 30896–30906 . October 2006 . 16916800 . 10.1074/jbc.M602840200 . free .
• Tian H, Liu X, Zhang B, Sun Q, Sun D . Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth . Acta Biochimica et Biophysica Sinica . 39 . 6 . 423–430 . June 2007 . 17558447 . 10.1111/j.1745-7270.2007.00294.x . free .
• Levin VA, Jochec JL, Shantz LM, Aldape KD . Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy . International Journal of Cancer . 121 . 10 . 2279–2283 . November 2007 . 17582600 . 10.1002/ijc.22914 . free .
• Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC . Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase . The Biochemical Journal . 409 . 1 . 187–192 . January 2008 . 17900240 . 10.1042/BJ20071004 .

Notes and References

1. Pitkänen LT, Heiskala M, Andersson LC . Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes . Biochemical and Biophysical Research Communications . 287 . 5 . 1051–1057 . October 2001 . 11587527 . 10.1006/bbrc.2001.5703 .
2. Zhu MY, Iyo A, Piletz JE, Regunathan S . Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine . Biochimica et Biophysica Acta (BBA) - General Subjects . 1670 . 2 . 156–164 . January 2004 . 14738999 . 3118518 . 10.1016/j.bbagen.2003.11.006 .
3. Web site: Entrez Gene: ADC arginine decarboxylase.
4. Pitkänen LT, Heiskala M, Andersson LC . Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes . Biochemical and Biophysical Research Communications . 287 . 5 . 1051–1057 . October 2001 . 11587527 . 10.1006/bbrc.2001.5703 .
5. Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC . Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase . The Biochemical Journal . 409 . 1 . 187–192 . January 2008 . 17900240 . 10.1042/BJ20071004 .
6. López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R . Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity . The Journal of Biological Chemistry . 281 . 41 . 30896–30906 . October 2006 . 16916800 . 10.1074/jbc.M602840200 . free .