AZIN1 explained

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.^{[1] [2] [3]}

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.^[3]

Further reading

• Murakami Y, Matsufuji S, Hayashi S . Degradation of ornithine decarboxylase by the 26S proteasome . Biochem. Biophys. Res. Commun. . 267 . 1 . 1–6 . 2000 . 10623564 . 10.1006/bbrc.1999.1706 . etal.
• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Imabayashi H, Mori T, Gojo S . Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis . Exp. Cell Res. . 288 . 1 . 35–50 . 2003 . 12878157 . 10.1016/S0014-4827(03)00130-7 . etal.
• Reuter TY, Medhurst AL, Waisfisz Q . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport . Exp. Cell Res. . 289 . 2 . 211–21 . 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S . Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor . Biochim Biophys Acta . 1353 . 3 . 209–16 . Nov 1997 . 9349715 . 10.1016/s0167-4781(97)00106-1.
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-Scale Concatenation cDNA Sequencing . Genome Res . 7 . 4 . 353–8 . Jun 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353.
3. Web site: Entrez Gene: AZIN1 antizyme inhibitor 1.