AZI2 explained

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.^{[1] [2]}

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM]

Further reading

• Funami K . Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA . J. Immunol. . 179 . 10 . 6867–72 . 2007 . 17982077 . 10.4049/jimmunol.179.10.6867. Sasai M . Ohba Y . Oshiumi . H . Seya . T . Matsumoto . M . free.
• Sasai M . NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction . J. Immunol. . 177 . 12 . 8676–83 . 2007 . 17142768 . 10.4049/jimmunol.177.12.8676. Shingai M . Funami K . Yoneyama . M . Fujita . T . Matsumoto . M . Seya . T . free .
• Sasai M . Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation . J. Immunol. . 174 . 1 . 27–30 . 2005 . 15611223 . 10.4049/jimmunol.174.1.27. Oshiumi H . Matsumoto M . Inoue . N . Fujita . F . Nakanishi . M . Seya . T . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Bouwmeester T . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . Bauch A . Ruffner H . Angrand . Pierre-Olivier . Bergamini . Giovanna . Croughton . Karen . Cruciat . Cristina . Eberhard . Dirk . Gagneur . Julien . 11683986 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Fujita F . Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling . Mol. Cell. Biol. . 23 . 21 . 7780–93 . 2003 . 14560022 . 10.1128/MCB.23.21.7780-7793.2003 . 207563 . Taniguchi Y . Kato T . Narita . Y. . Furuya . A. . Ogawa . T. . Sakurai . H. . Joh . T. . Itoh . M. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S . Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus . Gene . 240 . 2 . 289–95 . Jan 2000 . 10580148 . 10.1016/S0378-1119(99)00450-3 .
2. Web site: Entrez Gene: AZI2 5-azacytidine induced 2.