AZD-1390 explained

Legal Status:	Investigational
Cas Number:	2089288-03-7
Pubchem:	126689157
Unii:	CI43QFE22O
Chembl:	4594429
Chemspiderid:	67886355
Iuphar Ligand:	11277
Stdinchi:	1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3
Stdinchikey:	VQSZIPCGAGVRRP-UHFFFAOYSA-N
Smiles:	CC(C)N1C2=C(C=NC3=CC(=C(C=C32)C4=CN=C(C=C4)OCCCN5CCCCC5)F)N(C1=O)C
Iupac Name:	7-Fluoro-3-methyl-8-[6-(3-piperidin-1-ylpropoxy)pyridin-3-yl]-1-propan-2-ylimidazo[4,5-''c'']quinolin-2-one
C:	27
H:	32
F:	1
N:	5
O:	2

AZD-1390 is an experimental anticancer drug developed by AstraZeneca that inhibits ataxia telangiectasia mutated (ATM).^{[1] [2] [3] [4] [5] [6] [7]}

Notes and References

1. Dexheimer . Thomas S. . Coussens . Nathan P. . Silvers . Thomas . Wright . John . Morris . Joel . Doroshow . James H. . Teicher . Beverly A. . Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs . Cancer Research Communications . 25 August 2023 . 3 . 8 . 1648–1661 . 10.1158/2767-9764.CRC-23-0193. 37637936 . 10452929 .
2. Bannik . Kristina . Madas . Balázs . Jarke . Sabrina . Sutter . Andreas . Siemeister . Gerhard . Schatz . Christoph . Mumberg . Dominik . Zitzmann-Kolbe . Sabine . DNA repair inhibitors sensitize cells differently to high and low LET radiation . Scientific Reports . 1 December 2021 . 11 . 1 . 23257 . 10.1038/s41598-021-02719-9. 34853427 . 8636489 . 2021NatSR..1123257B .
3. Guha . Lahanya . Kumar . Hemant . Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications . Pharmaceutical Medicine . November 2023 . 37 . 6 . 463–490 . 10.1007/s40290-023-00499-3. 37698762 . 261694463 .
4. Fischer . Thomas . Hartmann . Oliver . Reissland . Michaela . Prieto-Garcia . Cristian . Klann . Kevin . Pahor . Nikolett . Schülein-Völk . Christina . Baluapuri . Apoorva . Polat . Bülent . Abazari . Arya . Gerhard-Hartmann . Elena . Kopp . Hans-Georg . Essmann . Frank . Rosenfeldt . Mathias . Münch . Christian . Flentje . Michael . Diefenbacher . Markus E. . PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy . Cell & Bioscience . 27 April 2022 . 12 . 1 . 50 . 10.1186/s13578-022-00778-7 . 35477555 . 9044846 . free .
5. Qi . Yinliang . Wang . Kun . Long . Bin . Yue . Hao . Wu . Yongshuo . Yang . Dexiao . Tong . Minghui . Shi . Xuan . Hou . Yunlei . Zhao . Yanfang . Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design . European Journal of Medicinal Chemistry . January 2023 . 246 . 114945 . 10.1016/j.ejmech.2022.114945. 36462444 . 254175697 .
6. Teicher . Beverly A. . Doyle . Austin . Wright . John . Kunos . Charles . Silvers . Thomas . Delosh . Rene . Laudeman . Julie . Reinhart . Russell . Ogle . Chad . Coussens . Nathan . Morris . Joel . Doroshow . James . Abstract 328: DNA damage inhibitors with topotecan in a complex spheroid model in PDM and established cell lines . Cancer Research . 15 August 2020 . 80 . 16_Supplement . 328 . 10.1158/1538-7445.AM2020-328. 225347744 .
7. Coussens . Nathan P. . Parchment . Ralph E. . Moscow . Jeffrey A. . Doyle . L. Austin . Delosh . René . Laudeman . Julie . Reinhart . Russell . Ogle . Chad . Silvers . Thomas . Dexheimer . Thomas S. . Morris . Joel . Teicher . Beverly A. . Doroshow . James H. . Abstract 1072: Combination screening of DNA damaging agents temozolomide and trabectedin with inhibitors of DNA repair using a complex spheroid model with a panel of patient-derived and established tumor cell lines . Cancer Research . 1 July 2021 . 81 . 13_Supplement . 1072 . 10.1158/1538-7445.AM2021-1072. 237868861 .