AUP1 explained
Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.[1] [2] [3]
Function
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.[3]
Interactions
AUP1 has been shown to interact with ITGA2B.
Further reading
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
- Karpisheva KV, Tauber B, Kisliakova TV, Dobner T . [A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines] . Tsitologiia . 44 . 9 . 846–51 . 2003 . 12534238 .
- Karpisheva KV, Touber B, Kisliakova TV, Dobner T . [A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans [sic] preliminary characterization of human AUP1 protein] . Tsitologiia . 44 . 9 . 839–45 . 2003 . 12534237 .
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 310934 . 10.1101/gr.140200 .
Notes and References
- Jang W, Weber JS, Bashir R, Bushby K, Meisler MH . Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13 . Genomics . 36 . 2 . 366–8 . Jan 1997 . 8812468 . 10.1006/geno.1996.0477 .
- Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K . Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3 . J Biol Chem . 277 . 32 . 28934–41 . Aug 2002 . 12042322 . 10.1074/jbc.M204340200 . free .
- Web site: Entrez Gene: AUP1 ancient ubiquitous protein 1.
