ATXN2L explained

Ataxin-2-like protein was initially identified in 1996 and designated Ataxin-2 Related protein (A2RP) as the search for the gene causing SCA2 lead to the identification of 2 cDNA clones with high similarity to ATXN2 (Pulst et al, 1996). It was later renamed as ATXN2L. It is a protein that in humans is encoded by the ATXN2L gene.^{[1] [2] [3]}

This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.^[4]

Interactions

ATXN2L has been shown to interact with Myeloproliferative leukemia virus oncogene.

References

• Pulst SM, Nechiporuk A, Nechiporuk T . Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. . Nat. Genet. . 14 . 3 . 269–76 . 1996 . 8896555 . 10.1038/ng1196-269 . 12365475 . etal.

Further reading

• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Pulst SM, Nechiporuk A, Nechiporuk T . Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. . Nat. Genet. . 14 . 3 . 269–76 . 1996 . 8896555 . 10.1038/ng1196-269 . 12365475 . etal.
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Brill LM, Salomon AR, Ficarro SB . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ong SE, Mittler G, Mann M . Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. . Nat. Methods . 1 . 2 . 119–26 . 2005 . 15782174 . 10.1038/nmeth715 . 6654604 .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Nonhoff U, Ralser M, Welzel F . Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. . Mol. Biol. Cell . 18 . 4 . 1385–96 . 2007 . 17392519 . 10.1091/mbc.E06-12-1120 . 1838996 . etal.

Notes and References

1. Meunier C, Bordereaux D, Porteu F, Gisselbrecht S, Chretien S, Courtois G . Cloning and characterization of a family of proteins associated with Mpl . J Biol Chem . 277 . 11 . 9139–47 . Mar 2002 . 11784712 . 10.1074/jbc.M105970200 . free .
2. Figueroa KP, Pulst SM . Identification and expression of the gene for human ataxin-2-related protein on chromosome 16 . Exp Neurol . 184 . 2 . 669–78 . Feb 2004 . 14769358 . 10.1016/S0014-4886(03)00287-5 . 10975750 .
3. Web site: Entrez Gene: ATXN2L ataxin 2-like.
4. Web site: Entrez Gene: ATXN2L ataxin 2-like.