Attractin Explained

Attractin is a protein that in humans is encoded by the ATRN gene.^{[1] [2] [3]}

Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.

Further reading

• Mori M, Sakurai M, Araie M . [Topical timolol and blood-aqueous barrier permeability to protein in human eyes] . Nippon Ganka Gakkai Zasshi . 96 . 11 . 1418–22 . 1993 . 1476071 .
• Nagase T . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . Ishikawa K . Miyajima N . 3 . Tanaka . A . Kotani . H . Nomura . N . Ohara . O . free .
• Nagle DL . The mahogany protein is a receptor involved in suppression of obesity . Nature . 398 . 6723 . 148–52 . 1999 . 10086355 . 10.1038/18210 . McGrail SH . Vitale J . 3 . Vitale . James . Woolf . Elizabeth A. . Dussault . Barry J. . Dirocco . Lisa . Holmgren . Lisa . Montagno . Jill . 1999Natur.398..148N . 4400267 .
• Gunn TM . The mouse mahogany locus encodes a transmembrane form of human attractin . Nature . 398 . 6723 . 152–6 . 1999 . 10086356 . 10.1038/18217 . Miller KA . He L . 3 . He . Lin . Hyman . Richard W. . Davis . Ronald W. . Azarani . Arezou . Schlossman . Stuart F. . Duke-Cohan . Jonathan S. . 1999Natur.398..152G . 4371433 .
• Tang W . Secreted and membrane attractin result from alternative splicing of the human ATRN gene . Proc. Natl. Acad. Sci. U.S.A. . 97 . 11 . 6025–30 . 2000 . 10811918 . 10.1073/pnas.110139897 . 18552 . Gunn TM . McLaughlin DF . 3 . Barsh . GS . Schlossman . SF . Duke-Cohan . JS . 2000PNAS...97.6025T . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gevaert K . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . Goethals M . Martens L . 3 . Van Damme . Jozef . Staes . An . Thomas . Grégoire R. . Vandekerckhove . Joël . 23783563 .
• Book: Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU . Isolation and Characterization of Attractin-2 . Dipeptidyl Aminopeptidases in Health and Disease . 524 . 109–13 . 2003 . 12675230 . 10.1007/0-306-47920-6_14 . Advances in Experimental Medicine and Biology . 0-306-47717-3 .
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR . Screening for N-glycosylated proteins by liquid chromatography mass spectrometry . Proteomics . 4 . 2 . 454–65 . 2004 . 14760718 . 10.1002/pmic.200300556 . 29261009 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Liu T . Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . Qian WJ . Gritsenko MA . 3 . Camp . David G. . Monroe . Matthew E. . Moore . Ronald J. . Smith . Richard D. .
• Wrenger S . Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function . J. Leukoc. Biol. . 80 . 3 . 621–9 . 2007 . 16835316 . 10.1189/jlb.1105678 . Faust J . Friedrich D . 3 . Hoffmann . T . Hartig . R . Lendeckel . U . Kähne . T . Thielitz . A . Neubert . K . 31858918 .

Notes and References

1. Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF . Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions . Proc Natl Acad Sci U S A . 95 . 19 . 11336–41 . Oct 1998 . 9736737 . 21643 . 10.1073/pnas.95.19.11336 . 1998PNAS...9511336D . free .
2. Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF . Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells . J Immunol . 156 . 5 . 1714–21 . Apr 1996 . 10.4049/jimmunol.156.5.1714 . 8596018 .
3. Web site: Entrez Gene: ATRN attractin.