ATP diphosphatase explained

ATP diphosphatase
Ec Number:	3.6.1.8
Cas Number:	37289-25-1
Go Code:	0047693

In enzymology, an ATP diphosphatase is an enzyme that catalyzes the chemical reaction

ATP + H₂O

\rightleftharpoons AMP + diphosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are AMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ATP diphosphohydrolase (diphosphate-forming). Other names in common use include ATPase, ATP pyrophosphatase, adenosine triphosphate pyrophosphatase, and ATP diphosphohydrolase [ambiguous]. This enzyme participates in purine metabolism and pyrimidine metabolism.

References

• HEPPEL LA, HILMOE RJ . 1953 . Mechanism of enzymatic hydrolysis of adenosinetriphosphate . J. Biol. Chem. . 202 . 217 - 26 . 13061448 . 1 .
• JOHNSON M, KAYE MA, HEMS R, KREBS HA . 1953 . Enzymic hydrolysis of adenosine phosphates by cobra venom . Biochem. J. . 54 . 625 - 9 . 13058963 . 4 . 1269107 .