ATPAF1 explained
ATP synthase mitochondrial F1 complex assembly factor 1, also known as ATP11 homolog, is a protein that in humans is encoded by the ATPAF1 gene.[1] [2]
Function
This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 beta subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. Alternatively spliced transcript variants have been identified, but the biological validity of some of these variants has not been determined.[1]
Further reading
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
- Ackerman SH . Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria . Biochim. Biophys. Acta . 1555 . 1–3 . 101–5 . 2002 . 12206899 . 10.1016/S0005-2728(02)00262-1 . free .
- Picková A, Paul J, Petruzzella V, Houstek J . Differential expression of ATPAF1 and ATPAF2 genes encoding F(1)-ATPase assembly proteins in mouse tissues . FEBS Lett. . 551 . 1–3 . 42–6 . 2003 . 12965202 . 10.1016/S0014-5793(03)00890-1 . free .
Notes and References
- Web site: Entrez Gene: ATP synthase mitochondrial F1 complex assembly factor 1.
- Wang ZG, White PS, Ackerman SH . Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria . J. Biol. Chem. . 276 . 33 . 30773–8 . August 2001 . 11410595 . 10.1074/jbc.M104133200 . free .
