ATP8B3 explained

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.^[1]

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

Further reading

• Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA . Differential expression of putative transbilayer amphipath transporters . Physiological Genomics . 1 . 3 . 139–50 . November 1999 . 11015572 . 10.1152/physiolgenomics.1999.1.3.139. 762447 .
• Harris MJ, Arias IM . FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1633 . 2 . 127–31 . July 2003 . 12880872 . 10.1016/S1388-1981(03)00107-0 .
• Fries AS, Svendsen O . Studies on Tyzzer's disease in rats . Laboratory Animals . 12 . 1 . 1–4 . January 1978 . 146761 . 10.1258/002367778780953297. 8184958 .
• Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M . Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry . Proceedings of the National Academy of Sciences of the United States of America . 106 . 18 . 7501–6 . May 2009 . 19416921 . 2678639 . 10.1073/pnas.0813386106 . 2009PNAS..106.7501S . free .

Notes and References

1. Web site: Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3. 2011-10-22 .