Renin receptor explained

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.^{[1] [2] [3]}

Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.^[4]

This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.^[3]

Further reading

• Kaneshiro Y, Ichihara A, Sakoda M . Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats . J. Am. Soc. Nephrol. . 18 . 6 . 1789–95 . 2007 . 17494887 . 10.1681/ASN.2006091062 . etal. free .
• Schefe JH, Menk M, Reinemund J . A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein . Circ. Res. . 99 . 12 . 1355–66 . 2007 . 17082479 . 10.1161/01.RES.0000251700.00994.0d . etal. free . 10.1.1.486.8053 .
• Kaneshiro Y, Ichihara A, Takemitsu T . Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats . Kidney Int. . 70 . 4 . 641–6 . 2006 . 16807542 . 10.1038/sj.ki.5001627 . etal. free .
• Burcklé CA, Jan Danser AH, Müller DN . Elevated blood pressure and heart rate in human renin receptor transgenic rats . Hypertension . 47 . 3 . 552–6 . 2006 . 16401765 . 10.1161/01.HYP.0000199912.47657.04 . etal. free .
• Huang Y, Wongamorntham S, Kasting J . Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms . Kidney Int. . 69 . 1 . 105–13 . 2006 . 16374430 . 10.1038/sj.ki.5000011 . etal. free .
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . etal. free .
• Ramser J, Abidi FE, Burckle CA . A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor . Hum. Mol. Genet. . 14 . 8 . 1019–27 . 2005 . 15746149 . 10.1093/hmg/ddi094 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hedera P, Alvarado D, Beydoun A, Fink JK . Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4 . Ann. Neurol. . 51 . 1 . 45–50 . 2002 . 11782983 . 10.1002/ana.10051 . 2027.42/34887 . 18107509 . free .
• Hu RM, Han ZG, Song HD . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . 2000PNAS...97.9543H . etal. free .

Notes and References

1. Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H . Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules . J Biol Chem . 273 . 18 . 10939–47 . Jun 1998 . 9556572 . 10.1074/jbc.273.18.10939 . free .
2. Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB . Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) . Mol Vis . 7 . 234–9 . Oct 2001 . 11590366 .
3. Web site: Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2.
4. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD . Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin . J. Clin. Invest. . 109 . 11 . 1417–27 . June 2002 . 12045255 . 150992 . 10.1172/JCI14276 .