ATP5S explained

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.^{[1] [2] [3]}

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.

External links

• • ATP5S: ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)

Further reading

• Kinosita K, Yasuda R, Noji H . F1-ATPase: a highly efficient rotary ATP machine . Essays Biochem. . 35 . 3–18 . 2003 . 12471886 . 10.1042/bse0350003.
• Oster G, Wang H . Rotary protein motors . Trends Cell Biol. . 13 . 3 . 114–21 . 2003 . 12628343 . 10.1016/S0962-8924(03)00004-7 .
• Leyva JA, Bianchet MA, Amzel LM . Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review) . Mol. Membr. Biol. . 20 . 1 . 27–33 . 2003 . 12745923 . 10.1080/0968768031000066532 . 218895820 . free .
• Sanadi DR, Pringle M, Kantham L . Evidence for the involvement of coupling factor B in the H+ channel of the mitochondrial H+-ATPase . Proc. Natl. Acad. Sci. U.S.A. . 81 . 5 . 1371–4 . 1984 . 6143319 . 10.1073/pnas.81.5.1371 . 344835 . 1984PNAS...81.1371S . etal. free .
• Yu W, Andersson B, Worley KC . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Elston T, Wang H, Oster G . Energy transduction in ATP synthase . Nature . 391 . 6666 . 510–3 . 1998 . 9461222 . 10.1038/35185 . 1998Natur.391..510E . 4406161 .
• Wang H, Oster G . Energy transduction in the F1 motor of ATP synthase . Nature . 396 . 6708 . 279–82 . 1998 . 9834036 . 10.1038/24409 . 1998Natur.396..279W . 4424498 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Cross RL . Molecular motors: turning the ATP motor . Nature . 427 . 6973 . 407–8 . 2004 . 14749816 . 10.1038/427407b . 2004Natur.427..407C . free .
• Ma J, Dempsey AA, Stamatiou D . Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects . Atherosclerosis . 191 . 1 . 63–72 . 2007 . 16806233 . 10.1016/j.atherosclerosis.2006.05.032 . etal.

Notes and References

1. Belogrudov GI, Hatefi Y . Factor B and the mitochondrial ATP synthase complex . J Biol Chem . 277 . 8 . 6097–103 . Feb 2002 . 11744738 . 10.1074/jbc.M111256200 . free .
2. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–13 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
3. Web site: Entrez Gene: ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B).