ATP5J2 explained

The ATP5MF gene^{[1] [2]} encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

Function

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Further reading

• Kinosita K, Yasuda R, Noji H . F1-ATPase: a highly efficient rotary ATP machine . Essays in Biochemistry . 35 . 3–18 . 2003 . 12471886 . 10.1042/bse0350003.
• Oster G, Wang H . Rotary protein motors . Trends in Cell Biology . 13 . 3 . 114–21 . Mar 2003 . 12628343 . 10.1016/S0962-8924(03)00004-7 .
• Leyva JA, Bianchet MA, Amzel LM . Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review) . Molecular Membrane Biology . 20 . 1 . 27–33 . 2003 . 12745923 . 10.1080/0968768031000066532 . 218895820 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Elston T, Wang H, Oster G . Energy transduction in ATP synthase . Nature . 391 . 6666 . 510–3 . Jan 1998 . 9461222 . 10.1038/35185 . 1998Natur.391..510E . 4406161 .
• Wang H, Oster G . Energy transduction in the F1 motor of ATP synthase . Nature . 396 . 6708 . 279–82 . Nov 1998 . 9834036 . 10.1038/24409 . 1998Natur.396..279W . 4424498 .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . Oct 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Bosetti F, Brizzi F, Barogi S, Mancuso M, Siciliano G, Tendi EA, Murri L, Rapoport SI, Solaini G . Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease . Neurobiology of Aging . 23 . 3 . 371–6 . 2002 . 11959398 . 10.1016/S0197-4580(01)00314-1 . 5621542 .
• Cross RL . Molecular motors: turning the ATP motor . Nature . 427 . 6973 . 407–8 . Jan 2004 . 14749816 . 10.1038/427407b . 2004Natur.427..407C . 52819856 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .

Notes and References

1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proceedings of the National Academy of Sciences of the United States of America . 95 . 14 . 8175–80 . Jul 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
2. Web site: Entrez Gene: ATP5MF ATP synthase membrane subunit f.