ATP5B explained

ATP synthase F1 subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5F1B gene.^{[1] [2]}

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.

Further reading

• Book: Maguire D, Shah J, McCabe M . Assaying ATP Synthase Rotor Activity . Oxygen Transport to Tissue XXVII . 578 . 67–72 . 2007 . 16927672 . 10.1007/0-387-29540-2_11 . 978-0-387-29543-5 . Advances in Experimental Medicine and Biology . https://archive.org/details/oxygentransportt0000inte/page/67 .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Ohta S, Kagawa Y . Human F1-ATPase: molecular cloning of cDNA for the beta subunit . J. Biochem. . 99 . 1 . 135–41 . 1986 . 2870059 . 10.1093/oxfordjournals.jbchem.a135452.
• Wallace DC, Ye JH, Neckelmann SN, Singh G, Webster KA, Greenberg BD . Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations . Curr. Genet. . 12 . 2 . 81–90 . 1988 . 2896550 . 10.1007/BF00434661 . 20431715 .
• Ohta S, Tomura H, Matsuda K, Kagawa Y . Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit . J. Biol. Chem. . 263 . 23 . 11257–62 . 1988 . 10.1016/S0021-9258(18)37950-X . 2900241 . free .
• Villena JA, Martin I, Viñas O, Cormand B, Iglesias R, Mampel T, Giralt M, Villarroya F . ETS transcription factors regulate the expression of the gene for the human mitochondrial ATP synthase beta-subunit . J. Biol. Chem. . 269 . 51 . 32649–54 . 1995 . 10.1016/S0021-9258(18)31683-1 . 7798271 . free .
• Abrahams JP, Leslie AG, Lutter R, Walker JE . Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria . Nature . 370 . 6491 . 621–8 . 1994 . 8065448 . 10.1038/370621a0 . 1994Natur.370..621A . 4275221 .
• Elston T, Wang H, Oster G . Energy transduction in ATP synthase . Nature . 391 . 6666 . 510–3 . 1998 . 9461222 . 10.1038/35185 . 1998Natur.391..510E . 4406161 .
• Wang H, Oster G . Energy transduction in the F1 motor of ATP synthase . Nature . 396 . 6708 . 279–82 . 1998 . 9834036 . 10.1038/24409 . 1998Natur.396..279W . 4424498 .
• Moser TL, Stack MS, Asplin I, Enghild JJ, Højrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV . Angiostatin binds ATP synthase on the surface of human endothelial cells . Proc. Natl. Acad. Sci. U.S.A. . 96 . 6 . 2811–6 . 1999 . 10077593 . 15851 . 10.1073/pnas.96.6.2811 . 1999PNAS...96.2811M . free .
• Wang ZG, White PS, Ackerman SH . Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria . J. Biol. Chem. . 276 . 33 . 30773–8 . 2001 . 11410595 . 10.1074/jbc.M104133200 . free .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
• Ackerman SH . Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria . Biochim. Biophys. Acta . 1555 . 1–3 . 101–5 . 2002 . 12206899 . 10.1016/S0005-2728(02)00262-1 . free .
• Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezón E, Champagne E, Pineau T, Georgeaud V, Walker JE, Tercé F, Collet X, Perret B, Barbaras R . Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis . Nature . 421 . 6918 . 75–9 . 2003 . 12511957 . 10.1038/nature01250 . 2003Natur.421...75M . 4333137 .
• Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport . Exp. Cell Res. . 289 . 2 . 211–21 . 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 .
• Cross RL . Molecular motors: turning the ATP motor . Nature . 427 . 6973 . 407–8 . 2004 . 14749816 . 10.1038/427407b . 2004Natur.427..407C . 52819856 . free .
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV . Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes . Biochem. J. . 383 . Pt 2 . 237–48 . 2005 . 15242332 . 1134064 . 10.1042/BJ20040647 .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free .

Notes and References

1. Neckelmann N, Warner CK, Chung A, Kudoh J, Minoshima S, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Liu JD . The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression . Genomics . 5 . 4 . 829–43 . Jan 1990 . 2687158 . 10.1016/0888-7543(89)90125-0 .
2. Web site: Entrez Gene: ATP5F1B ATP synthase F1 subunit beta.