ATP12A explained

Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.^{[1] [2] [3] [4]}

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[2]

Further reading

• Modyanov NN, Petrukhin KE, Sverdlov VE . The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. . FEBS Lett. . 278 . 1 . 91–4 . 1991 . 1847115 . 10.1016/0014-5793(91)80091-G . etal. free .
• Yang-Feng TL, Schneider JW, Lindgren V . Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. . Genomics . 2 . 2 . 128–38 . 1988 . 2842249 . 10.1016/0888-7543(88)90094-8 . etal.
• Shull MM, Lingrel JB . Multiple genes encode the human Na+,K+-ATPase catalytic subunit. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 12 . 4039–43 . 1987 . 3035563 . 10.1073/pnas.84.12.4039 . 305017 . free .
• Sverdlov ED, Monastyrskaya GS, Broude NE . The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. . FEBS Lett. . 217 . 2 . 275–8 . 1987 . 3036582 . 10.1016/0014-5793(87)80677-4 . etal. free .
• Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN . Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family. . FEBS Lett. . 349 . 1 . 144–50 . 1994 . 8045293 . 10.1016/0014-5793(94)00655-5 . free .
• Sverdlov VE, Kostina MB, Modyanov NN . Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase. . Genomics . 32 . 3 . 317–27 . 1997 . 8838794 . 10.1006/geno.1996.0125 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Pestov NB, Romanova LG, Korneenko TV . Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. . FEBS Lett. . 440 . 3 . 320–4 . 1999 . 9872395 . 10.1016/S0014-5793(98)01483-5 . 83264565 . etal. free .
• Pestov NB, Korneenko TV, Adams G . Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization. . Am. J. Physiol., Cell Physiol. . 282 . 4 . C907–16 . 2002 . 11880279 . 10.1152/ajpcell.00258.2001 . 19898937 . etal.
• Reinhardt J, Kosch M, Lerner M . Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1. . Am. J. Physiol. Renal Physiol. . 283 . 2 . F335–43 . 2002 . 12110518 . 10.1152/ajprenal.00226.2001 . 7158036 . etal.
• Takahashi Y, Sakai H, Kuragari M . Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. . Jpn. J. Physiol. . 52 . 3 . 317–21 . 2003 . 12230809 . 10.2170/jjphysiol.52.317 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Li J, Codina J, Petroske E . The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function. . Kidney Int. . 65 . 4 . 1301–10 . 2004 . 15086469 . 10.1111/j.1523-1755.2004.00507.x . etal. free .
• Johansson M, Jansson T, Pestov NB, Powell TL . Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. . Placenta . 25 . 6 . 505–11 . 2004 . 15135233 . 10.1016/j.placenta.2003.11.008 .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.

Notes and References

1. Web site: ATP12A - Potassium-transporting ATPase alpha chain 2 - Homo sapiens (Human) - ATP12A gene & protein . www.uniprot.org . 9 April 2022 . en.
2. Web site: Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide.
3. Sverdlov VE, Kostina MB, Modyanov NN . Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase . Genomics . 32 . 3 . 317–27 . March 1996 . 8838794 . 10.1006/geno.1996.0125 .
4. Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U . Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes . Genomics . 2 . 2 . 128–38 . February 1988 . 2842249 . 10.1016/0888-7543(88)90094-8.