ATOH8 (gene) explained

Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene.^[1] It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.^[2] In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.^[3]

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 2945168 . 10.2337/dc10-0452 .
• Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi B . Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor . PLOS ONE . 6 . 8 . e23005 . 2011 . 21857980 . 3150394 . 10.1371/journal.pone.0023005 . 2011PLoSO...623005C . free .
• Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M . ATOH8: a novel marker in human muscle fiber regeneration . Histochem. Cell Biol. . 143 . 5 . 443–52 . 2015 . 25514850 . 10.1007/s00418-014-1299-6 . 9753058 .

Notes and References

1. Web site: Entrez Gene: Atonal bHLH transcription factor 8. 2016-10-19.
2. Schroeder . Nadine . Wuelling . Manuela . Hoffmann . Daniel . Brand-Saberi . Beate . Vortkamp . Andrea . 2019-08-26 . van Wijnen . Andre . Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones . PLOS ONE . en . 14 . 8 . e0218230 . 10.1371/journal.pone.0218230 . 1932-6203 . 6709907 . 31449527 . 2019PLoSO..1418230S . free .
3. Takács . Roland . Vágó . Judit . Póliska . Szilárd . Pushparaj . Peter Natesan . Ducza . László . Kovács . Patrik . Jin . Eun-Jung . Barrett-Jolley . Richard . Zákány . Róza . Matta . Csaba . 2023-03-29 . The temporal transcriptomic signature of cartilage formation . Nucleic Acids Research . 51 . 8 . 3590–3617 . 10.1093/nar/gkad210 . 1362-4962 . 36987858. 10164575 .